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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically focused on practical aspects of the research design, like the recruitment process and consent as well as adherence to the use of commonly available equipment.
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Pragmatic is a software company that provides a variety of casino games available on online gambling platforms. Pragmatic's iGaming solutions are utilized by the leading operators and casinos that are located in the land. The company provides front-end design tools, analysis tools, marketing, promotions and payment systems, as well as security, customer service, and bug reporting. In addition, the company provides its players a safe and secure environment with high-quality graphics and games.
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A practical trial that employs various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be valid and also reduces the chance of bias in the results. Too much heterogeneity, however, can cause problems with the design of the trial.
Pragmatic Play is also a major player in the live casino market, offering an extensive selection of table games that are classic such as Blackjack and Roulette in a variety of versions. The live studios of the company in Romania and Malta offer customers an authentic gaming experience as well a full selection of virtual betting options. The company also offers a variety of games that make online gambling more enjoyable and engaging. Some of these shows have live hosts, whereas others are hosted by famous personalities from the industry.
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Pragmatic Play has earned a name for itself by providing top-quality games and an outstanding user experience. Its software can be used on mobile devices and in multiple languages. Despite its infancy it has already established itself as a top casino gaming platform. Wolves is one of the most recent releases which is a five-reel slot machine that has a high RTP and impressive graphics. Its other notable titles are Wolf Gold and Chilli Heat.
The goal of pragmatic trials is to simulate real-life scenarios and to achieve maximum credibility externally. They are usually requested by policy makers and practitioners to inform their decision making. They can also be used to determine the causality of an intervention with its outcomes. They should not, however be used to replace the need for explanation studies.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials should be used to replace explanation tests or if they should serve as an addition to them. Schwartz and Lellouch1 made the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the decision-making process for policy and practice. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic research study, including recruitment, design, delivery of the intervention, and follow-up.
There is a growing increase in the number pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.